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Basic SMTP reply code · RFC 5321

421 Service not available

The server is unavailable and closes the connection; it may answer any command this way. It is temporary: the sending server retries.

How 421 appears at providers

The exact text from the provider's documentation, as you see it in the bounce, and what it means.

Gmail

Microsoft 365 / Exchange Online

Have the whole error message?

The whole bounce, a line like 550 5.7.26 … or the DSN fields (Status:, Diagnostic-Code:). At most 64 KB.

The text is read in memory only and not kept.

Sources: RFC 5321 · RFC 3463 · RFC 3464 · IANA · Gmail · Microsoft 365 · read on 26 September 2026